Gripper Set
The distance between the gripper handles after setting the gripper has a significant impact on difficulty of closing the gripper. The most common styles of gripper sets are parallel, credit card width, and no set. The further the handles are from close after the set, the more difficult the gripper will be to close. Outside of the greater closing distance, the leverage on the gripper handles is reduced via less favorable positioning of the gripper with wider sets.
Impact of hand size on closing a gripper with varying set widths is often debated. An individual with small hands will have greater difficulty obtaining good leverage with a wide gripper set than an individual with large hands. Practice is needed to learn to generate maximum power with any setting style and largely offsets the impact of hand size.